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Literature DB >> 19629446

TRPA1 agonists delay gastric emptying in rats through serotonergic pathways.

Hitoshi Doihara¹, Katsura Nozawa, Eri Kawabata-Shoda, Ryosuke Kojima, Toshihide Yokoyama, Hiroyuki Ito.

Abstract

Our recent study found that TRPA1 is highly expressed in enterochromaffin cells and that stimulation of these cells with TRPA1 agonists enhances 5-hydroxytryptamine (5-HT) secretion in vitro. Here, to demonstrate the 5-HT-releasing effect of TRPA1 agonists in vivo, we examined the effect of TRPA1 agonists on gastric emptying in rats. The results showed that TRPA1 agonists dose-dependently delayed gastric emptying. Further, the effects of TRPA1 agonists on this delay were abolished in rats treated with a TRPA1 antagonist, an inhibitor of tryptophan hydroxylase, or a 5-HT(3) receptor antagonist. Taken together, these results indicate that TRPA1 agonists delay in vivo gastric emptying through serotonergic pathways.

Entities: Chemical Gene Species

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Year: 2009 PMID： 19629446 DOI： 10.1007/s00210-009-0435-7

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

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