Literature DB >> 19629066

Therapy: Growth hormone supplementation: a silver lining for the aged?

Paul Lee, Ken K Y Ho.   

Abstract

Previous randomized, controlled studies of growth hormone supplementation in the elderly have reported body-composition improvements but no beneficial effect on strength or physical function. The findings of a new study, however, hint at a potential benefit from the treatment for elderly individuals with functional decline.

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Year:  2009        PMID: 19629066     DOI: 10.1038/nrendo.2009.144

Source DB:  PubMed          Journal:  Nat Rev Endocrinol        ISSN: 1759-5029            Impact factor:   43.330


  10 in total

1.  Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Authors:  X M Guan; H Yu; O C Palyha; K K McKee; S D Feighner; D J Sirinathsinghji; R G Smith; L H Van der Ploeg; A D Howard
Journal:  Brain Res Mol Brain Res       Date:  1997-08

2.  The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial.

Authors:  Manthos G Giannoulis; Peter H Sonksen; Margot Umpleby; Louise Breen; Claire Pentecost; Martin Whyte; Carolyn V McMillan; Clare Bradley; Finbarr C Martin
Journal:  J Clin Endocrinol Metab       Date:  2005-12-06       Impact factor: 5.958

3.  Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial.

Authors:  Marc R Blackman; John D Sorkin; Thomas Münzer; Michele F Bellantoni; Jan Busby-Whitehead; Thomas E Stevens; Jocelyn Jayme; Kieran G O'Connor; Colleen Christmas; Jordan D Tobin; Kerry J Stewart; Ernest Cottrell; Carol St Clair; Katharine M Pabst; S Mitchell Harman
Journal:  JAMA       Date:  2002-11-13       Impact factor: 56.272

4.  Effects of an oral growth hormone secretagogue in older adults.

Authors:  Heidi K White; Charles D Petrie; William Landschulz; David MacLean; Ann Taylor; Kenneth Lyles; Jeanne Y Wei; Andrew R Hoffman; Roberto Salvatori; Mark P Ettinger; Miriam C Morey; Marc R Blackman; George R Merriam
Journal:  J Clin Endocrinol Metab       Date:  2009-01-27       Impact factor: 5.958

5.  Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity.

Authors:  Arancha Delgado-Rubín de Célix; Julie A Chowen; Jesús Argente; Laura M Frago
Journal:  J Neurochem       Date:  2006-11       Impact factor: 5.372

6.  Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.

Authors:  Ralf Nass; Suzan S Pezzoli; Mary Clancy Oliveri; James T Patrie; Frank E Harrell; Jody L Clasey; Steven B Heymsfield; Mark A Bach; Mary Lee Vance; Michael O Thorner
Journal:  Ann Intern Med       Date:  2008-11-04       Impact factor: 25.391

Review 7.  Systematic review: the effects of growth hormone on athletic performance.

Authors:  Hau Liu; Dena M Bravata; Ingram Olkin; Anne Friedlander; Vincent Liu; Brian Roberts; Eran Bendavid; Olga Saynina; Shelley R Salpeter; Alan M Garber; Andrew R Hoffman
Journal:  Ann Intern Med       Date:  2008-03-17       Impact factor: 25.391

8.  Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men.

Authors:  Klara Sjögren; Kin-Chuen Leung; Warren Kaplan; Margaret Gardiner-Garden; James Gibney; Ken K Y Ho
Journal:  Am J Physiol Endocrinol Metab       Date:  2007-04-24       Impact factor: 4.310

9.  Growth hormone replacement in healthy older men improves body composition but not functional ability.

Authors:  M A Papadakis; D Grady; D Black; M J Tierney; G A Gooding; M Schambelan; C Grunfeld
Journal:  Ann Intern Med       Date:  1996-04-15       Impact factor: 25.391

10.  Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.

Authors:  D R Taaffe; L Pruitt; J Reim; R L Hintz; G Butterfield; A R Hoffman; R Marcus
Journal:  J Clin Endocrinol Metab       Date:  1994-11       Impact factor: 5.958

  10 in total

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