PURPOSE: To report a case of a complete regression of choroidal metastasis secondary to non-small-cell lung cancer (NSCLC). METHODS: Retrospective case review of a female patient treated with intravitreal bevacizumab and oral erlotinib combination therapy for choroidal metastases secondary to NSCLC. Best corrected visual acuity (BCVA), fluorescein angiography (FA), optical coherence tomography (OCT), and B-scan ultrasonography were compared during the 4-month treatment period. RESULTS: Four weeks after the third injection of bevacizumab (2.5 mg), the BCVA had improved to 20/40 from 20/200 and the 2 subretinal masses had completely disappeared. FA demonstrated only a retinal pigment epithelial (RPE) window defect with minimal to no leakage. In the B-scan ultrasonography and OCT, no further mass-like lesion was detected. The retina and RPE layer were flattened. CONCLUSION: Combining intravitreal bevacizumab and oral erlotinib could be another treatment option for patients with choroidal metastasis of NSCLC. Copyright 2009 S. Karger AG, Basel.
PURPOSE: To report a case of a complete regression of choroidal metastasis secondary to non-small-cell lung cancer (NSCLC). METHODS: Retrospective case review of a female patient treated with intravitreal bevacizumab and oral erlotinib combination therapy for choroidal metastases secondary to NSCLC. Best corrected visual acuity (BCVA), fluorescein angiography (FA), optical coherence tomography (OCT), and B-scan ultrasonography were compared during the 4-month treatment period. RESULTS: Four weeks after the third injection of bevacizumab (2.5 mg), the BCVA had improved to 20/40 from 20/200 and the 2 subretinal masses had completely disappeared. FA demonstrated only a retinal pigment epithelial (RPE) window defect with minimal to no leakage. In the B-scan ultrasonography and OCT, no further mass-like lesion was detected. The retina and RPE layer were flattened. CONCLUSION: Combining intravitreal bevacizumab and oral erlotinib could be another treatment option for patients with choroidal metastasis of NSCLC. Copyright 2009 S. Karger AG, Basel.
Authors: Akshay Gopinathan Nair; Haresh T Asnani; Vinod C Mehta; Siddharth V Mehta; Rima S Pathak; Amit H Palkar; Indumati Gopinathan Journal: Ocul Oncol Pathol Date: 2016-09-14
Authors: Jonathan W Riess; Seema Nagpal; Millie Das; Joel W Neal; Jonathan W Kim; Heather A Wakelee Journal: J Thorac Oncol Date: 2013-02 Impact factor: 15.609