| Literature DB >> 19628407 |
Kari Dugger1, Thomas W Lowder, Torry A Tucker, Lisa M Schwiebert.
Abstract
Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.Entities:
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Year: 2009 PMID： 19628407 PMCID： PMC2749080 DOI： 10.1016/j.smim.2009.06.002
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130