| Literature DB >> 19628385 |
Céline Pinheiro1, Adhemar Longatto-Filho, Kleber Simões, Carlos Eduardo Jacob, Cláudio José Caldas Bresciani, Bruno Zilberstein, Ivan Cecconello, Venâncio Avancini Ferreira Alves, Fernando Schmitt, Fátima Baltazar.
Abstract
The aim of the present work was to assess the role of monocarboxylate transporters (MCTs), namely MCT1 and MCT4 as well as MCT/CD147 co-expression in gastric tissues and evaluate their clinico-pathological significance in gastric carcinoma. For that, we analysed the immunohistochemical expression of MCT1, MCT4 and CD147, in a large series of gastric samples, including non-neoplastic, tumour and metastatic tissues. A significant decrease in MCT4 plasma membrane expression was observed from non-neoplastic to gastric primary malignant tissues and to lymph-node metastasis and both MCT1 and MCT4 correlated with CD147. Importantly, both MCT4 and CD147 were more frequently expressed in Lauren's intestinal-type tumours and MCT1/CD147 co-expression was associated with advanced gastric carcinoma, Lauren's intestinal type, TNM staging and lymph-node metastasis. Our results showed that the prognostic value of CD147 was associated with MCT1 co-expression in gastric cancer cells, supporting the view that CD147 plasma membrane activity is dependent on MCT co-expression.Entities:
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Year: 2009 PMID： 19628385 DOI： 10.1016/j.ejca.2009.06.018
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162