OBJECTIVE: We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads. STUDY DESIGN: Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-beta3 gene. RESULTS: Only 1 of the TGF-beta3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratio(multi-locus adj), 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-beta3 variants had no effect on risk of PIH. CONCLUSION: A fetal TGF-beta3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.
OBJECTIVE: We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads. STUDY DESIGN:Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-beta3 gene. RESULTS: Only 1 of the TGF-beta3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratio(multi-locus adj), 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-beta3 variants had no effect on risk of PIH. CONCLUSION: A fetal TGF-beta3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.
Authors: J C Cross; D Baczyk; N Dobric; M Hemberger; M Hughes; D G Simmons; H Yamamoto; J C P Kingdom Journal: Placenta Date: 2003 Feb-Mar Impact factor: 3.481
Authors: Melissa L Wilson; Doerthe Brueggmann; Daniel H Desmond; John E Mandeville; T Murphy Goodwin; Sue Ann Ingles Journal: Int J Mol Epidemiol Genet Date: 2011-05-05
Authors: Zahra Mobasher; Muhammad T Salam; T Murphy Goodwin; Frederick Lurmann; Sue A Ingles; Melissa L Wilson Journal: Environ Res Date: 2013-03-21 Impact factor: 6.498
Authors: Kathryn J Gray; Vesela P Kovacheva; Hooman Mirzakhani; Andrew C Bjonnes; Berta Almoguera; Andrew T DeWan; Elizabeth W Triche; Audrey F Saftlas; Josephine Hoh; Dale L Bodian; Elisabeth Klein; Kathi C Huddleston; Sue Ann Ingles; Charles J Lockwood; Hakon Hakonarson; Thomas F McElrath; Jeffrey C Murray; Melissa L Wilson; Errol R Norwitz; S Ananth Karumanchi; Brian T Bateman; Brendan J Keating; Richa Saxena Journal: Hypertension Date: 2018-07-02 Impact factor: 10.190