Literature DB >> 19628

An approach to peripheral vasodilator-beta-adrenergic blocking agents.

J J Baldwin, R Hirschmann, P K Lumma, W C Lumma, G S Ponticello, C S Sweet, A Scriabine.   

Abstract

The syntheses of 2-phenyl- and 2-pyridyl-4-trifluoromethylimidazoles having a 3-tert-butylamino-2-hydroxypropoxy moiety attached to the aryl or heteroaryl substituent are described. Structure--activity relationships based on results from an evaluation of these compounds for antihypertensive, vasodilating, and beta-adrenergic blocking activities are discussed.

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Year:  1977        PMID： 19628     DOI： 10.1021/jm00218a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Pharmacologic characterization in vitro and in vivo of iodine 123-labeled derivatives of the beta-adrenoceptor antagonist CGP12177, designed for the imaging of cardiac beta-receptors.

Authors:  E A Dubois; G A Somsen; J C van den Bos; A G Janssen; G J Boer; H D Batink; E A van Royen; M Pfaffendorf; P A van Zwieten
Journal:  J Nucl Cardiol       Date:  1996 May-Jun       Impact factor: 5.952

2.  Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs.

Authors:  A Scriabine; C T Ludden; G Morgan; J J Baldwin
Journal:  Experientia       Date:  1979-12-15

3.  Antihypertensive and other cardiovascular effects of 2-(3-pyridyl)- and 2-(4-pyridyl)-4-trifluoromethylimidazoles.

Authors:  A Scriabine; C T Ludden; L S Watson; J M Stavorski; G Morgan; J J Baldwin
Journal:  Experientia       Date:  1979-05-15
  3 in total

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