Literature DB >> 19626458

CREB, a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis.

Ping Wang1, Jin Xu, Cheng Zhang.   

Abstract

Our previous reports indicated that cyclic AMP response element-binding (CREB) protein was involved in the regulation of Bcl-2 expression in apoptotic HeLa cells induced by trichosanthin (TCS). Here we presented that blockade the binding site of CREB to Bcl-2 by a CRE decoy oligonucleotide abrogated the TCS-decreased Bcl-2 expression. Furthermore, overexpression of phosphorylated CREB (p-CREB) in cells transfected with p-CREB/GFP fusion construct resulted in an increase of Bcl-2 protein content, however, this increase was attenuated by TCS treatment. Therefore, this data supports the hypothesis that CREB is a possible upstream regulator of Bcl-2 in apoptotic HeLa cells induced by TCS. The study provides new insights into understanding the mechanism of TCS in the treatment of cervical cancer.

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Year:  2009        PMID： 19626458     DOI： 10.1007/s11033-009-9629-9

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  22 in total

1.  Trichosanthin-induced specific changes of cytoskeleton configuration were associated with the decreased expression level of actin and tubulin genes in apoptotic Hela cells.

Authors:  Ping Wang; Ji-Cheng Li
Journal:  Life Sci       Date:  2007-08-23       Impact factor: 5.037

Review 2.  BCL-2 family: regulators of cell death.

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Journal:  Annu Rev Immunol       Date:  1998       Impact factor: 28.527

3.  Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.

Authors:  Jennifer R Chao; Yan G Ni; Carlos A Bolaños; Zia Rahman; Ralph J DiLeone; Eric J Nestler
Journal:  Eur J Neurosci       Date:  2002-10       Impact factor: 3.386

4.  Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.

Authors:  G A Gonzalez; M R Montminy
Journal:  Cell       Date:  1989-11-17       Impact factor: 41.582

5.  Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.

Authors:  S Pugazhenthi; E Miller; C Sable; P Young; K A Heidenreich; L M Boxer; J E Reusch
Journal:  J Biol Chem       Date:  1999-09-24       Impact factor: 5.157

6.  Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis.

Authors:  B E Wilson; E Mochon; L M Boxer
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

7.  Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells.

Authors:  Harsimran S Saini; Karen M Gorse; Linda M Boxer; Carmen Sato-Bigbee
Journal:  J Neurochem       Date:  2004-05       Impact factor: 5.372

8.  Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells.

Authors:  Ziming Yu; Dinesh M Shah
Journal:  Gynecol Oncol       Date:  2007-06-27       Impact factor: 5.482

9.  Selective killing of choriocarcinoma cells in vitro by trichosanthin, a plant protein purified from root tubers of the Chinese medicinal herb Trichosanthes kirilowii.

Authors:  S W Tsao; K T Yan; H W Yeung
Journal:  Toxicon       Date:  1986       Impact factor: 3.033

10.  Trichosanthin suppresses HeLa cell proliferation through inhibition of the PKC/MAPK signaling pathway.

Authors:  Ping Wang; Li-Li Chen; Hui Yan; Ji-Cheng Li
Journal:  Cell Biol Toxicol       Date:  2008-08-28       Impact factor: 6.691
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  9 in total

1.  Increase of cytosolic calcium induced by trichosanthin suppresses cAMP/PKC levels through the inhibition of adenylyl cyclase activity in HeLa cells.

Authors:  Qingsong Jiang; Tumen Bai; Shunhua Shen; Lei Li; Haoliang Ding; Ping Wang
Journal:  Mol Biol Rep       Date:  2010-11-19       Impact factor: 2.316

2.  Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery.

Authors:  Yingzhi Chen; Meng Zhang; Hongyue Jin; Dongdong Li; Fan Xu; Aihua Wu; Jinyu Wang; Yongzhuo Huang
Journal:  Theranostics       Date:  2017-08-15       Impact factor: 11.556

Review 3.  Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein.

Authors:  Wei-Wei Shi; Kam-Bo Wong; Pang-Chui Shaw
Journal:  Toxins (Basel)       Date:  2018-08-20       Impact factor: 4.546

4.  Pokeweed antiviral protein increases HIV-1 particle infectivity by activating the cellular mitogen activated protein kinase pathway.

Authors:  Sheila Mansouri; Meherzad Kutky; Katalin A Hudak
Journal:  PLoS One       Date:  2012-05-01       Impact factor: 3.240

5.  Cyclic AMP-response element regulated cell cycle arrests in cancer cells.

Authors:  Ping Wang; Shuaishuai Huang; Feng Wang; Yu Ren; Michael Hehir; Xue Wang; Jie Cai
Journal:  PLoS One       Date:  2013-06-28       Impact factor: 3.240

Review 6.  Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review.

Authors:  Ou Sha; Junfei Niu; Tzi-Bun Ng; Eric Yu-Pang Cho; Xiaoyuan Fu; Wenqi Jiang
Journal:  Cancer Chemother Pharmacol       Date:  2013-02-03       Impact factor: 3.333

7.  Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2.

Authors:  Haihui Zhuang; Xiangyu Meng; Yanyuan Li; Xue Wang; Shuaishuai Huang; Kaitai Liu; Michael Hehir; Rong Fang; Lei Jiang; Jeff X Zhou; Ping Wang; Yu Ren
Journal:  Oncotarget       Date:  2016-03-29

8.  Fordin: A novel type I ribosome inactivating protein from Vernicia fordii modulates multiple signaling cascades leading to anti-invasive and pro-apoptotic effects in cancer cells in vitro.

Authors:  Weili Lu; Yingji Mao; Xue Chen; Jun Ni; Rui Zhang; Yuting Wang; Jun Wang; Lifang Wu
Journal:  Int J Oncol       Date:  2018-07-04       Impact factor: 5.650

9.  Trichosanthin inhibits cervical cancer by regulating oxidative stress-induced apoptosis.

Authors:  Chenglu Zhu; Cuilan Zhang; Xiaoming Cui; Jing Wu; Zhizhu Cui; Xiaojuan Shen
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  9 in total

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