Literature DB >> 1962566

Cytochrome b561, ascorbic acid, and transmembrane electron transfer.

P J Fleming1, U M Kent.   

Abstract

Cytochrome b561 is a transmembrane protein unique to neuroendocrine secretory vesicles. It acts as an electron channel and mediates equilibration of ascorbate-semidehydroascorbate inside the secretory vesicle with the ascorbate redox pair in the cytoplasm. The role for this function is to regenerate ascorbate inside the secretory vesicle for use by monooxygenases. Elucidation of the structure and mechanism of redox activity of cytochrome b561 may demonstrate paradigms for other ascorbate-utilizing enzymes as well as provide insights into long-range biological electron transfer.

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Year:  1991        PMID： 1962566     DOI： 10.1093/ajcn/54.6.1173s

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN： 0002-9165            Impact factor:   7.045


  13 in total

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