BACKGROUND: Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS). OBJECTIVE: We report a case of FAS as an initial symptom of a MS. METHODS: A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed. RESULTS: Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS. CONCLUSION: FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.
BACKGROUND:Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS). OBJECTIVE: We report a case of FAS as an initial symptom of a MS. METHODS: A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed. RESULTS: Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS. CONCLUSION:FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.
Authors: Vincenzo Di Stefano; Antonella Maria Pia De Novellis; Fedele Dono; Marco Onofrj; Maria Vittoria De Angelis Journal: Neurol Sci Date: 2019-06-20 Impact factor: 3.307
Authors: Stefanie Keulen; Jo Verhoeven; Louis De Page; Roel Jonkers; Roelien Bastiaanse; Peter Mariën Journal: Front Hum Neurosci Date: 2016-04-19 Impact factor: 3.169
Authors: Stefanie Keulen; Jo Verhoeven; Elke De Witte; Louis De Page; Roelien Bastiaanse; Peter Mariën Journal: Front Hum Neurosci Date: 2016-04-27 Impact factor: 3.169