| Literature DB >> 19624101 |
Michel Obringer1, Marie Barbarotto, Sabine Choppin, Françoise Colobert.
Abstract
Efficient synthesis of the fragment C9-C16 bearing the anti,syn stereotriad of ansamycin antibiotics is described. Key steps for controlling the configuration of the three stereogenic centers involve a stereoselective Reformatsky-type reaction followed by a diastereoselective reduction of a beta-ketosulfoxide.Entities:
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Year: 2009 PMID： 19624101 DOI： 10.1021/ol901144j
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005