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Literature DB >> 19623690

Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.

Abstract

Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Interleukin-7

Year: 2009 PMID： 19623690 PMCID： PMC2797310 DOI： 10.1111/j.1365-2796.2009.02085.x

Source DB: PubMed Journal: J Intern Med ISSN： 0954-6820 Impact factor: 8.989

114 in total

1. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.

Authors: Thomas Calzascia; Marc Pellegrini; Albert Lin; Kristine M Garza; Alisha R Elford; Arda Shahinian; Pamela S Ohashi; Tak W Mak
Journal: Proc Natl Acad Sci U S A Date: 2008-02-14 Impact factor: 11.205

2. Importance of interleukin-7 in the development of experimental graft-versus-host disease.

Authors: Brile Chung; Eric Dudl; Akira Toyama; Lora Barsky; Kenneth I Weinberg
Journal: Biol Blood Marrow Transplant Date: 2007-12-03 Impact factor: 5.742

Review 3. Interleukin-7 in rheumatoid arthritis.

Authors: S M Churchman; F Ponchel
Journal: Rheumatology (Oxford) Date: 2008-03-20 Impact factor: 7.580

Review 4. Immune activation and inflammation in HIV-1 infection: causes and consequences.

Authors: V Appay; D Sauce
Journal: J Pathol Date: 2008-01 Impact factor: 7.996

5. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.

Authors: Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Naoya Sakamoto; Mamoru Watanabe
Journal: J Immunol Date: 2008-01-01 Impact factor: 5.422

Review 6. Interleukin-7 receptor signaling network: an integrated systems perspective.

Authors: Megan J Palmer; Vinay S Mahajan; Lily C Trajman; Darrell J Irvine; Douglas A Lauffenburger; Jianzhu Chen
Journal: Cell Mol Immunol Date: 2008-04 Impact factor: 11.530

7. Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.

Authors: Valerie I Brown; Jessica Hulitt; Jonathan Fish; Cecilia Sheen; Marlo Bruno; Qing Xu; Martin Carroll; Junjie Fang; David Teachey; Stephan A Grupp
Journal: Cancer Res Date: 2007-10-15 Impact factor: 12.701

8. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.

Authors: Nuno L Alves; Ester M M van Leeuwen; Ingrid A M Derks; René A W van Lier
Journal: J Immunol Date: 2008-04-15 Impact factor: 5.422

9. Association of serum interleukin-7 levels with the development of acute graft-versus-host disease.

Authors: Robert M Dean; Terry Fry; Crystal Mackall; Seth M Steinberg; Fran Hakim; Daniel Fowler; Jeanne Odom; Jason Foley; Ronald Gress; Michael R Bishop
Journal: J Clin Oncol Date: 2008-11-10 Impact factor: 44.544

10. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets.

Authors: Claude Sportès; Frances T Hakim; Sarfraz A Memon; Hua Zhang; Kevin S Chua; Margaret R Brown; Thomas A Fleisher; Michael C Krumlauf; Rebecca R Babb; Catherine K Chow; Terry J Fry; Julie Engels; Renaud Buffet; Michel Morre; Robert J Amato; David J Venzon; Robert Korngold; Andrew Pecora; Ronald E Gress; Crystal L Mackall
Journal: J Exp Med Date: 2008-06-23 Impact factor: 14.307

34 in total

1. Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Authors: Yuichiro Shindo; Anja G Fuchs; Christopher G Davis; Tim Eitas; Jacqueline Unsinger; Carey-Ann D Burnham; Jonathan M Green; Michel Morre; Grant V Bochicchio; Richard S Hotchkiss
Journal: J Leukoc Biol Date: 2016-09-14 Impact factor: 4.962

Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.

1. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.

2. Importance of interleukin-7 in the development of experimental graft-versus-host disease.

Review 3. Interleukin-7 in rheumatoid arthritis.

Review 4. Immune activation and inflammation in HIV-1 infection: causes and consequences.

5. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.

Review 6. Interleukin-7 receptor signaling network: an integrated systems perspective.

7. Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.

8. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.

9. Association of serum interleukin-7 levels with the development of acute graft-versus-host disease.

10. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets.

1. Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Review 2. Cytokines in the Treatment of Cancer.

Review 3. Naive T cell homeostasis: from awareness of space to a sense of place.

4. Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.

Review 5. Dying to protect: cell death and the control of T-cell homeostasis.

6. Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.

Review 7. Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.

Review 8. The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.

9. IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes.

10. IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice.