BACKGROUND AND PURPOSE: Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement. METHOD: We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading. RESULTS: Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6. CONCLUSION: Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CD patients.
BACKGROUND AND PURPOSE: Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement. METHOD: We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading. RESULTS: Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6. CONCLUSION: Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CDpatients.
Authors: Brian D Berman; Christopher L Groth; Stefan H Sillau; Sarah Pirio Richardson; Scott A Norris; Johanna Junker; Norbert Brüggemann; Pinky Agarwal; Richard L Barbano; Alberto J Espay; Joaquin A Vizcarra; Christine Klein; Tobias Bäumer; Sebastian Loens; Stephen G Reich; Marie Vidailhet; Cecilia Bonnet; Emmanuel Roze; Hyder A Jinnah; Joel S Perlmutter Journal: J Neurol Neurosurg Psychiatry Date: 2019-12-17 Impact factor: 10.154
Authors: Meng Wang; Tolulope Sajobi; Francesca Morgante; Charles Adler; Pinky Agarwal; Tobias Bäumer; Alfredo Berardelli; Brian D Berman; Joel Blumin; Max Borsche; Allison Brashear; Andres Deik; Kevin Duque; Alberto J Espay; Gina Ferrazzano; Jeanne Feuerstein; Susan Fox; Samuel Frank; Mark Hallett; Joseph Jankovic; Mark S LeDoux; Julie Leegwater-Kim; Abhimanyu Mahajan; Irene A Malaty; William Ondo; Alexander Pantelyat; Sarah Pirio-Richardson; Emmanuel Roze; Rachel Saunders-Pullman; Oksana Suchowersky; Daniel Truong; Marie Vidailhet; Aparna Wagle Shukla; Joel S Perlmutter; Hyder A Jinnah; Davide Martino Journal: Eur J Neurol Date: 2021-08-04 Impact factor: 6.288