The impact of pedigree structure on heritability estimates.

Heritability measures the familial aggregation of a disease or trait and a non-zero heritability suggests that a genetic component may be present. Reliable heritability estimates are necessary in the planning phase of a linkage or genetic association study but often these estimates are obtained from other studies where the composition of pedigrees may be different from the study that is prepared. The impact of pedigree structure on precision and accuracy of heritability estimates is examined for data and models both with and without dominance effects. Analytical and simulation results find that for purely additive genetic effects all but the simplest pedigree structures provide the same information about the heritability of a quantitative trait. In the presence of dominance effects there is a substantial difference in the precision obtained by different pedigree structures. Copyright 2009 S. Karger AG, Basel.