AIM: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. METHODS:Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, including frequency, severity and duration of migraine attacks. RESULTS: There was a mean reduction of 0.54 and 0.94 attacks/month with placebo and BoNT-A, respectively, and absolute attack count was less in the verum group (3.6 vs. 4.2 attacks/month), but this was not statistically significant. The patients' global assessment of efficacy was significantly better than placebo in the high-dose group (p = 0.02) but no effects were seen for the other secondary efficacy parameters. CONCLUSION: Our study showed a trend towards a reduced attack rate with verum but did not show any statistically significant efficacy of BoNT-A in the prophylactic treatment of migraine. 2009 S. Karger AG, Basel
RCT Entities:
AIM: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. METHODS:Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, including frequency, severity and duration of migraine attacks. RESULTS: There was a mean reduction of 0.54 and 0.94 attacks/month with placebo and BoNT-A, respectively, and absolute attack count was less in the verum group (3.6 vs. 4.2 attacks/month), but this was not statistically significant. The patients' global assessment of efficacy was significantly better than placebo in the high-dose group (p = 0.02) but no effects were seen for the other secondary efficacy parameters. CONCLUSION: Our study showed a trend towards a reduced attack rate with verum but did not show any statistically significant efficacy of BoNT-A in the prophylactic treatment of migraine. 2009 S. Karger AG, Basel
Authors: Clare P Herd; Claire L Tomlinson; Caroline Rick; W J Scotton; Julie Edwards; Natalie Ives; Carl E Clarke; Alexandra Sinclair Journal: Cochrane Database Syst Rev Date: 2018-06-25
Authors: Enrico Ferrari; Chunjing Gu; Dhevahi Niranjan; Laura Restani; Christine Rasetti-Escargueil; Ilona Obara; Sandrine M Geranton; Jason Arsenault; Tom A Goetze; Callista B Harper; Tam H Nguyen; Elizabeth Maywood; John O'Brien; Giampietro Schiavo; Daniel W Wheeler; Frederic A Meunier; Michael Hastings; J Michael Edwardson; Dorothea Sesardic; Matteo Caleo; Stephen P Hunt; Bazbek Davletov Journal: Bioconjug Chem Date: 2013-09-20 Impact factor: 4.774