Literature DB >> 19622000

Cynomolgus monkey CYPs: a comparison with human CYPs.

K Iwasaki1, Y Uno.   

Abstract

Characteristics of twelve cytochromes P450 (CYPs) from cynomolgus monkeys were compared with those of human CYPs that play an important role in drug metabolism. Eleven members of CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, and CYP3A subfamilies from cynomolgus monkeys exhibited a high degree of homologies (more than 90%) in cDNA and amino acid sequences with corresponding human CYPs, and catalysed typical reactions of corresponding human CYPs. One member of the cynomolgus monkey CYP2C subfamily, CYP2C76, exhibited a lower homology (around 70%) in amino acid sequences with other cynomolgus monkey and human CYP2C subfamilies. CYP2C76 catalysed typical CYP2C substrates with low activities, and has not been found in humans. CYPs identified in cynomolgus monkeys were similar to CYP1A1, CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, and CYP3A5 in humans. These results indicate that cynomolgus monkeys express CYPs similar to human CYPs that are important in drug metabolism.

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Year:  2009        PMID： 19622000     DOI： 10.1080/00498250903003135

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  8 in total

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2.  Drug Transporters in Xenobiotic Disposition and Pharmacokinetic Prediction.

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4.  Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research.

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5.  Maternal obesity alters feto-placental cytochrome P4501A1 activity.

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6.  Pharmacokinetics of buprenorphine following intravenous and intramuscular administration in male rhesus macaques (Macaca mulatta).

Authors:  K R Kelly; B H Pypendop; K L Christe
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7.  CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement.

Authors:  Wujian Ju; Sihyung Yang; John H Ansede; Chad E Stephens; Arlene S Bridges; Robert D Voyksner; Mohamed A Ismail; David W Boykin; Richard R Tidwell; James Edwin Hall; Michael Zhuo Wang
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8.  Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension.

Authors:  Anita S Y Chan; Tin Aung Tun; John C Allen; Myoe Naing Lynn; Sai Bo Bo Tun; Veluchamy Amutha Barathi; Michaël J A Girard; Tin Aung; Makoto Aihara
Journal:  Sci Rep       Date:  2020-09-07       Impact factor: 4.379
  8 in total

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