PURPOSE: Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants. METHODS: In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis. RESULTS: Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively, p = 0.05) and a significant FFM loss (7.61%, p < 0.01) in patients with severe malnutrition at admission. CONCLUSIONS: Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.
PURPOSE:Malnutrition is prevalent in cancerpatients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancerpatients during chemotherapy treatment and to identify their significant determinants. METHODS: In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis. RESULTS:Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively, p = 0.05) and a significant FFM loss (7.61%, p < 0.01) in patients with severe malnutrition at admission. CONCLUSIONS: Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.
Authors: Angel Segura; Josep Pardo; Carlos Jara; Luis Zugazabeitia; Joan Carulla; Ramón de Las Peñas; Encarna García-Cabrera; María Luz Azuara; Josefina Casadó; Carmen Gómez-Candela Journal: Clin Nutr Date: 2005-10 Impact factor: 7.324
Authors: R J Freedman; N Aziz; D Albanes; T Hartman; D Danforth; S Hill; N Sebring; J C Reynolds; J A Yanovski Journal: J Clin Endocrinol Metab Date: 2004-05 Impact factor: 5.958
Authors: Paolo Cotogni; Paolo Pedrazzoli; Elisabeth De Waele; Giuseppe Aprile; Gabriella Farina; Silvia Stragliotto; Francesco De Lorenzo; Riccardo Caccialanza Journal: J Cancer Date: 2019-07-10 Impact factor: 4.207
Authors: Zeynep Gülsüm Güç; Ahmet Alacacıoğlu; Mehmet Eren Kalender; Utku Oflazoğlu; Sinan Ünal; Yaşar Yıldız; Tarık Salman; Yüksel Küçükzeybek; Mustafa Oktay Tarhan Journal: Front Nutr Date: 2022-08-18