OBJECTIVE: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. MAIN OUTCOME MEASURES: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. RESULTS: Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal. CONCLUSIONS: Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.
OBJECTIVE: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. MAIN OUTCOME MEASURES: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. RESULTS: Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal. CONCLUSIONS:Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.
Authors: Patricia A Schachern; Vladimir Tsuprun; Sebahatin Cureoglu; Patricia A Ferrieri; David E Briles; Michael M Paparella; Steven K Juhn Journal: Arch Otolaryngol Head Neck Surg Date: 2010-11
Authors: Patricia A Schachern; Vladimir Tsuprun; Sarah Goetz; Sebahattin Cureoglu; Steven K Juhn; David E Briles; Michael M Paparella; Patricia Ferrieri Journal: JAMA Otolaryngol Head Neck Surg Date: 2013-09 Impact factor: 6.223
Authors: Marianne F L van den Broek; Ilke De Boeck; Filip Kiekens; An Boudewyns; Olivier M Vanderveken; Sarah Lebeer Journal: Clin Microbiol Rev Date: 2019-07-03 Impact factor: 26.132
Authors: Patricia A Schachern; Vladimir Tsuprun; Patricia Ferrieri; David E Briles; Sarah Goetz; Sebahattin Cureoglu; Michael M Paparella; Steven Juhn Journal: Int J Pediatr Otorhinolaryngol Date: 2014-06-24 Impact factor: 1.675
Authors: Longhuan Ma; Colleen Sedney; Yang Su; Kalyan K Dewan; Bodo Linz; Eric T Harvill Journal: Front Cell Infect Microbiol Date: 2022-03-11 Impact factor: 5.293