BACKGROUND: Psoriasis is a common, nonulcerative skin disorder. OBSERVATIONS: We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death. CONCLUSIONS: The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
BACKGROUND: Psoriasis is a common, nonulcerative skin disorder. OBSERVATIONS: We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death. CONCLUSIONS: The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
Authors: Maria Estela Martinez-Escala; Alba L Posligua; Heather Wickless; Audrey Rutherford; Kimberly A Sable; Belen Rubio-Gonzalez; Xiaolong A Zhou; Jason B Kaplan; Barbara Pro; Jaehyuk Choi; Christiane Querfeld; Steven T Rosen; Joan Guitart Journal: J Am Acad Dermatol Date: 2018-01-04 Impact factor: 11.527
Authors: Joan Guitart; M Estela Martinez-Escala; Antonio Subtil; Madeleine Duvic; Melissa P Pulitzer; Elise A Olsen; Ellen Kim; Alain H Rook; Sara S Samimi; Gary S Wood; Michael Girardi; Jacqueline Junkins-Hopkins; Doina S Ivan; M Angelica Selim; Kimberly A Sable; Pooja Virmani; Laura B Pincus; Michael T Tetzlaff; Jinah Kim; Youn H Kim Journal: Mod Pathol Date: 2017-01-27 Impact factor: 7.842
Authors: N A Trum; J Zain; X U Martinez; V Parekh; M Afkhami; F Abdulla; K R Carson; S T Rosen; C L Bennett; C Querfeld Journal: Br J Dermatol Date: 2021-10-20 Impact factor: 9.302