| Literature DB >> 19620004 |
David H Williams1, Fiona Adam, David R Fenwick, Juin Fok-Seang, Iain Gardner, Duncan Hay, Rawal Jaiessh, Donald S Middleton, Charles E Mowbray, Tanya Parkinson, Manos Perros, Christopher Pickford, Michelle Platts, Amy Randall, Daniel Siddle, Peter T Stephenson, Thien-Duc Tran, Hannah Vuong.
Abstract
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral profiles of selected compounds are also presented.Entities:
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Year: 2009 PMID： 19620004 DOI： 10.1016/j.bmcl.2009.06.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823