| Literature DB >> 19619673 |
C Janssen1, S Beloka, P Kayembe, G Deboeck, D Adamopoulos, R Naeije, P van de Borne.
Abstract
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.Entities:
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Year: 2009 PMID： 19619673 DOI： 10.1016/j.resp.2009.07.010
Source DB: PubMed Journal: Respir Physiol Neurobiol ISSN： 1569-9048 Impact factor: 1.931