| Literature DB >> 19618898 |
Le Thi Kim Van1, Tran Manh Hung, Phuong Thien Thuong, Tran Minh Ngoc, Jin Cheol Kim, Han-Su Jang, Xing Fu Cai, Sei Ryang Oh, Byung-Sun Min, Mi Hee Woo, Jae Sue Choi, Hyeong Kyu Lee, Kihwan Bea.
Abstract
The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3alpha-hydroxyolean-12-en-23,29-dioic acid (1), 3beta-hydroxyolean-12-en-23,29-dioic acid (2), 3beta,23-dihydroxyolean-12-en-29-oic acid (3), 3alpha-O-acetylolean-12-en-23,27-dioic acid (4), 3alpha-O-caffeoylolean-12-en-27-oic acid (5), 3alpha-O-acetylolean-12-en-23,29-dioic acid (6), and 3alpha-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC(50) values of 7.63 and 6.56 microM, respectively.Entities:
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Year: 2009 PMID： 19618898 DOI： 10.1021/np900273z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050