Literature DB >> 19618455

WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

Suzie A Noronha1, Jason E Farrar, Todd A Alonzo, Robert B Gerbing, Norman J Lacayo, Gary V Dahl, Yaddanapudi Ravindranath, Robert J Arceci, David M Loeb.   

Abstract

WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

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Year:  2009        PMID： 19618455      PMCID： PMC2926132          DOI： 10.1002/pbc.22142

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  20 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring.

Authors:  L Boublikova; M Kalinova; J Ryan; F Quinn; A O'Marcaigh; O Smith; P Browne; J Stary; S R McCann; J Trka; M Lawler
Journal:  Leukemia       Date:  2006-02       Impact factor: 11.528

3.  Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000.

Authors:  Y Ravindranath; M Chang; C P Steuber; D Becton; G Dahl; C Civin; B Camitta; A Carroll; S C Raimondi; H J Weinstein
Journal:  Leukemia       Date:  2005-12       Impact factor: 11.528

4.  Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.

Authors:  K Inoue; H Tamaki; H Ogawa; Y Oka; T Soma; T Tatekawa; Y Oji; A Tsuboi; E H Kim; M Kawakami; T Akiyama; T Kishimoto; H Sugiyama
Journal:  Blood       Date:  1998-04-15       Impact factor: 22.113

5.  Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia.

Authors:  Iris H I M Hollink; Marry M van den Heuvel-Eibrink; Martin Zimmermann; Brian V Balgobind; Susan T C J M Arentsen-Peters; Marielle Alders; Andre Willasch; Gertjan J L Kaspers; Jan Trka; Andre Baruchel; Siebold S N de Graaf; Ursula Creutzig; Rob Pieters; Dirk Reinhardt; C Michel Zwaan
Journal:  Blood       Date:  2009-01-26       Impact factor: 22.113

6.  Cardiomyopathy in children with Down syndrome treated for acute myeloid leukemia: a report from the Children's Oncology Group Study POG 9421.

Authors:  Maureen M O'Brien; Jeffrey W Taub; Myron N Chang; Gita V Massey; Kimo C Stine; Susana C Raimondi; David Becton; Yaddanapudi Ravindranath; Gary V Dahl
Journal:  J Clin Oncol       Date:  2008-01-20       Impact factor: 44.544

7.  Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia.

Authors:  A Gaiger; D Schmid; G Heinze; B Linnerth; H Greinix; P Kalhs; K Tisljar; S Priglinger; K Laczika; M Mitterbauer; M Novak; G Mitterbauer; C Mannhalter; O A Haas; K Lechner; U Jäger
Journal:  Leukemia       Date:  1998-12       Impact factor: 11.528

8.  Expression of Wilms' tumor gene 1 at different stages of acute myeloid leukemia and analysis of its major splice variants.

Authors:  Jan M Siehl; Mark Reinwald; Karin Heufelder; Hans D Menssen; Ulrich Keilholz; Eckhard Thiel
Journal:  Ann Hematol       Date:  2004-08-31       Impact factor: 3.673

9.  Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry.

Authors:  J Trka; M Kalinová; O Hrusák; J Zuna; O Krejcí; J Madzo; P Sedlácek; V Vávra; K Michalová; M Jarosová; J Starý
Journal:  Leukemia       Date:  2002-07       Impact factor: 11.528

10.  An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation.

Authors:  D M Loeb; J L Summers; E A Burwell; D Korz; A D Friedman; S Sukumar
Journal:  Leukemia       Date:  2003-05       Impact factor: 11.528
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  7 in total

1.  High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group.

Authors:  Akira Shimada; Tomohiko Taki; Daisuke Koga; Ken Tabuchi; Akio Tawa; Ryoji Hanada; Masahiro Tsuchida; Keizo Horibe; Ichiro Tsukimoto; Souichi Adachi; Seiji Kojima; Yasuhide Hayashi
Journal:  Int J Hematol       Date:  2012-08-23       Impact factor: 2.490

Review 2.  Prognostic factors in pediatric acute myeloid leukemia.

Authors:  Mohamed Radhi; Soheil Meshinchi; Alan Gamis
Journal:  Curr Hematol Malig Rep       Date:  2010-10       Impact factor: 3.952

3.  Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.

Authors:  Phoenix A Ho; Rong Zeng; Todd A Alonzo; Robert B Gerbing; Kristen L Miller; Jessica A Pollard; Derek L Stirewalt; Nyla A Heerema; Susana C Raimondi; Betsy Hirsch; Janet L Franklin; Beverly Lange; Soheil Meshinchi
Journal:  Blood       Date:  2010-04-22       Impact factor: 22.113

4.  WT1 Expression in Adult Acute Myeloid Leukemia: Assessing its Presence, Magnitude and Temporal Changes as Prognostic Factors.

Authors:  Zsófia Ujj; Gergely Buglyó; Miklós Udvardy; Dániel Beyer; György Vargha; Sándor Biró; László Rejtő
Journal:  Pathol Oncol Res       Date:  2015-11-04       Impact factor: 3.201

5.  WT1 mutation in pediatric patients with acute myeloid leukemia: a report from the Japanese Childhood AML Cooperative Study Group.

Authors:  Hirozumi Sano; Akira Shimada; Ken Tabuchi; Tomohiko Taki; Chisato Murata; Myoung-ja Park; Kentaro Ohki; Manabu Sotomatsu; Souichi Adachi; Akio Tawa; Ryoji Kobayashi; Keizo Horibe; Masahiro Tsuchida; Ryoji Hanada; Ichiro Tsukimoto; Yasuhide Hayashi
Journal:  Int J Hematol       Date:  2013-08-27       Impact factor: 2.490

6.  Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells.

Authors:  Gregory McCarty; David M Loeb
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240

7.  Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice.

Authors:  Colleen E Annesley; Cara Rabik; Amy S Duffield; Rachel E Rau; Daniel Magoon; Li Li; Vicki Huff; Donald Small; David M Loeb; Patrick Brown
Journal:  Oncotarget       Date:  2018-10-19
  7 in total

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