PURPOSE: This study was designed to evaluate whether preoperative chemoradiotherapy reduces the number of lymph nodes harvested after total mesorectal excision of rectal cancer. METHODS: From January 1995 to December 2007, 168 consecutive patients with rectal cancer underwent total mesorectal excision in the Department of Surgical Oncology at the University of Crete. The patients were divided into three groups (Group A, no chemoradiotherapy; Group B, short course of chemoradiotherapy; Group C, long course of chemoradiotherapy). The primary end points were the number of lymph nodes examined and the percentage of patients with fewer than 12 lymph nodes removed. RESULTS: The overall number of lymph nodes retrieved was not significantly reduced by the use of preoperative chemoradiotherapy. The percentage of patients with fewer than 12 lymph nodes examined, however, was significantly higher in Group C. The leakage rate and the duration of hospital stay were not affected. The rate of wound infections was higher in Group C. CONCLUSION: Preoperative chemoradiotherapy did not significantly decrease the overall number of lymph nodes retrieved but did increase the percentage of patients with fewer than 12 lymph nodes examined.
PURPOSE: This study was designed to evaluate whether preoperative chemoradiotherapy reduces the number of lymph nodes harvested after total mesorectal excision of rectal cancer. METHODS: From January 1995 to December 2007, 168 consecutive patients with rectal cancer underwent total mesorectal excision in the Department of Surgical Oncology at the University of Crete. The patients were divided into three groups (Group A, no chemoradiotherapy; Group B, short course of chemoradiotherapy; Group C, long course of chemoradiotherapy). The primary end points were the number of lymph nodes examined and the percentage of patients with fewer than 12 lymph nodes removed. RESULTS: The overall number of lymph nodes retrieved was not significantly reduced by the use of preoperative chemoradiotherapy. The percentage of patients with fewer than 12 lymph nodes examined, however, was significantly higher in Group C. The leakage rate and the duration of hospital stay were not affected. The rate of wound infections was higher in Group C. CONCLUSION: Preoperative chemoradiotherapy did not significantly decrease the overall number of lymph nodes retrieved but did increase the percentage of patients with fewer than 12 lymph nodes examined.
Authors: Chiaojung Jillian Tsai; Christopher H Crane; John M Skibber; Miguel A Rodriguez-Bigas; George J Chang; Barry W Feig; Cathy Eng; Sunil Krishnan; Dipen M Maru; Prajnan Das Journal: Cancer Date: 2011-02-15 Impact factor: 6.860
Authors: Sherif R Z Abdel-Misih; Lai Wei; Al B Benson; Steven Cohen; Lily Lai; John Skibber; Neal Wilkinson; Martin Weiser; Deborah Schrag; Tanios Bekaii-Saab Journal: J Natl Compr Canc Netw Date: 2016-12 Impact factor: 11.908
Authors: S R Markar; B J Noordman; H Mackenzie; J M Findlay; P R Boshier; M Ni; E W Steyerberg; A van der Gaast; M C C M Hulshof; N Maynard; M I van Berge Henegouwen; B P L Wijnhoven; J V Reynolds; J J B Van Lanschot; G B Hanna Journal: Ann Oncol Date: 2017-03-01 Impact factor: 32.976