Literature DB >> 1961740

Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.

O D Ratnoff1, B Everson, P Embury, N P Ziats, J M Anderson, M M Emanuelson, C J Malemud.   

Abstract

The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.

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Year:  1991        PMID： 1961740      PMCID： PMC53006          DOI： 10.1073/pnas.88.23.10740

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Removal of heparin and protamine from plasma.

Authors:  A R Thompson; R B Counts
Journal:  J Lab Clin Med       Date:  1976-12

2.  Bovine coronary artery endothelium: in vitro culture and production of plasminogen activator.

Authors:  N P Ziats; G H Goldsmith; E D Medvedeff; A L Robertson
Journal:  Thromb Res       Date:  1986-01-15       Impact factor: 3.944

3.  Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va.

Authors:  D M Stern; P P Nawroth; K Harris; C T Esmon
Journal:  J Biol Chem       Date:  1986-01-15       Impact factor: 5.157

4.  Inhibition of contact activation by platelet factor 4.

Authors:  M F Scully; K Weerasinghe; V V Kakkar
Journal:  Thromb Res       Date:  1980-11-15       Impact factor: 3.944

Review 5.  The haemostatic function of the vascular endothelial cell.

Authors:  H A Bull; S J Machin
Journal:  Blut       Date:  1987-08

6.  Characterization of the effects of cultured vascular cells on the activation of blood coagulation.

Authors:  G M Rodgers; C S Greenberg; M A Shuman
Journal:  Blood       Date:  1983-06       Impact factor: 22.113

7.  Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q.

Authors:  E H Rehmus; B M Greene; B A Everson; O D Ratnoff
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

8.  beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway.

Authors:  I Schousboe
Journal:  Blood       Date:  1985-11       Impact factor: 22.113

9.  Purification of Hageman factor (factor XII) on columns of popcorn-agarose.

Authors:  O D Ratnoff; B Everson; V H Donaldson; B H Mitchell
Journal:  Blood       Date:  1986-06       Impact factor: 22.113

10.  Activation of Hageman factor (factor XII) by sulfatides and other agents in the absence of plasma proteases.

Authors:  F España; O D Ratnoff
Journal:  J Lab Clin Med       Date:  1983-07
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  2 in total

1.  Why does the blood not coagulate?

Authors:  O D Ratnoff
Journal:  West J Med       Date:  1993-02

2.  Endothelial cells produce a substance that inhibits contact activation of coagulation by blocking the activation of Hageman factor.

Authors:  J Kleniewski; V H Donaldson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205
  2 in total

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