| Literature DB >> 19616959 |
Takuto Hasegawa1, Yoshihiko Kondo, Yukio Koizumi, Toshihiro Sugiyama, Akane Takeda, Shinichi Ito, Fumio Hamada.
Abstract
Two kinds of rhodamine modified beta-cyclodextrins (R-1 and R-2), which are coupled up ethylene diamine (EDA) and tetraethylene pentamine (TEPA) between Rh B and beta-cyclodextrin, respectively, have been synthesized. R-1 and 2 work as a new fluorogenic probe for monitoring pH of Hela cells, and MTT of assay R-1, R-2, and rhodamine B indicate that less a cytotoxicity of those R-1 and R-2 than that of rhodamine B, where R-1 has much less one than that of R-2. The fluorogenetic probe capability of R-2 was recognized in an area of acidic area in living cell, which is lysosome.Entities:
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Year: 2009 PMID： 19616959 DOI： 10.1016/j.bmc.2009.06.046
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641