Literature DB >> 19616958

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.

Takayoshi Suzuki1, Keiko Imai, Erika Imai, Shinsuke Iida, Ryuzo Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata.   

Abstract

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.

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Year:  2009        PMID： 19616958     DOI： 10.1016/j.bmc.2009.07.001

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.

Authors:  Melanie Gertz; Frank Fischer; Giang Thi Tuyet Nguyen; Mahadevan Lakshminarasimhan; Mike Schutkowski; Michael Weyand; Clemens Steegborn
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-09       Impact factor: 11.205

Review 2.  Rejuvenating sirtuins: the rise of a new family of cancer drug targets.

Authors:  Santina Bruzzone; Marco Daniele Parenti; Alessia Grozio; Alberto Ballestrero; Inga Bauer; Alberto Del Rio; Alessio Nencioni
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

3.  Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells.

Authors:  Tomohiro Kozako; Takayoshi Suzuki; Makoto Yoshimitsu; Yuichiro Uchida; Ayako Kuroki; Akiyoshi Aikawa; Shin-ichiro Honda; Naomichi Arima; Shinji Soeda
Journal:  Sci Rep       Date:  2015-06-19       Impact factor: 4.379

4.  Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.

Authors:  Yunan Sun; Hui Zhou; Hongmei Zhu; Siu-wai Leung
Journal:  Sci Rep       Date:  2016-01-25       Impact factor: 4.379

5.  Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.

Authors:  Tomohiro Kozako; Paolo Mellini; Takeo Ohsugi; Akiyoshi Aikawa; Yu-Ichiro Uchida; Shin-Ichiro Honda; Takayoshi Suzuki
Journal:  BMC Cancer       Date:  2018-08-06       Impact factor: 4.430

6.  Possible Contribution of Inflammation-Associated Hypoxia to Increased K2P5.1 K+ Channel Expression in CD4+ T cells of the Mouse Model for Inflammatory Bowel Disease.

Authors:  Kyoko Endo; Hiroaki Kito; Ryo Tanaka; Junko Kajikuri; Satoshi Tanaka; Elghareeb E Elboray; Takayoshi Suzuki; Susumu Ohya
Journal:  Int J Mol Sci       Date:  2019-12-19       Impact factor: 5.923
  6 in total

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