| Literature DB >> 19616956 |
Anna-Maria Monforte1, Patrizia Logoteta, Stefania Ferro, Laura De Luca, Nunzio Iraci, Giovanni Maga, Erik De Clercq, Christophe Pannecouque, Alba Chimirri.
Abstract
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have become very important components in the antiretroviral combination therapies used to treat HIV. Recently, our group identified some 1,3-dihydrobenzimidazol-2-one derivatives and their sulfones as a potent and novel class of NNRTIs. We herein report the synthesis and biological evaluation of the new compounds in which different structural modifications have been introduced in order to investigate their effects on RT inhibition.Entities:
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Year: 2009 PMID： 19616956 DOI： 10.1016/j.bmc.2009.06.068
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641