| Literature DB >> 19616947 |
Christopher J Burns1, Michael F Harte, Xianyong Bu, Emmanuelle Fantino, Max Joffe, Harrison Sikanyika, Stephen Su, C Elisabet Tranberg, Neil Wilson, Susan A Charman, David M Shackleford, Andrew F Wilks.
Abstract
CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.Entities:
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Year: 2009 PMID： 19616947 DOI： 10.1016/j.bmcl.2009.06.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823