OBJECTIVES: The aim of our study was to determine whether the activities of galactose-1-phosphate uridyltransferase and UDP-galactose-4'-epimerase are correlated, and in what way they may influence one another. DESIGN AND METHODS: Enzyme activities were measured in red blood cells from 214 individuals. RESULTS: A statistically significant (p<0.001) positive correlation was observed between GALT and GALE activities. CONCLUSIONS: Our results suggest that GALT and GALE activities are correlated and that GALE activity has a greater impact on GALT activity than vice versa.
OBJECTIVES: The aim of our study was to determine whether the activities of galactose-1-phosphate uridyltransferase and UDP-galactose-4'-epimerase are correlated, and in what way they may influence one another. DESIGN AND METHODS: Enzyme activities were measured in red blood cells from 214 individuals. RESULTS: A statistically significant (p<0.001) positive correlation was observed between GALT and GALE activities. CONCLUSIONS: Our results suggest that GALT and GALE activities are correlated and that GALE activity has a greater impact on GALT activity than vice versa.
Authors: Minela Haskovic; Ana I Coelho; Jörgen Bierau; Jo M Vanoevelen; Laura K M Steinbusch; Luc J I Zimmermann; Eduardo Villamor-Martinez; Gerard T Berry; M Estela Rubio-Gozalbo Journal: J Inherit Metab Dis Date: 2020-01-14 Impact factor: 4.982