| Literature DB >> 19616429 |
David G Washburn1, Tram H Hoang, James S Frazee, Latisha Johnson, Marlys Hammond, Sharada Manns, Kevin P Madauss, Shawn P Williams, Chaya Duraiswami, Thuy B Tran, Eugene L Stewart, Eugene T Grygielko, Lindsay E Glace, Walter Trizna, Rakesh Nagilla, Jeffrey D Bray, Scott K Thompson.
Abstract
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In addition, these compounds had improved selectivity against hERG channel inhibition.Entities:
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Year: 2009 PMID： 19616429 DOI： 10.1016/j.bmcl.2009.06.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823