Literature DB >> 19616285

Free radical theory of aging: implications in male infertility.

Nisarg Desai1, Edmund Sabanegh, Taesoo Kim, Ashok Agarwal.   

Abstract

This review examines the effect of mitochondrial generation of reactive oxygen species (ROS) and aging on human spermatozoa and seminal antioxidants. We discuss the effect of continuous ROS production on biomarkers of aging, such as germ cell telomeres and telomerase, lipofuscin, and amyloid. These markers may be responsible for telomere shortening and subsequent decrease in sperm count, decline in testosterone concentration, and decline in motility with aging. Excessive ROS can also damage mitochondrial deoxyribonucleic acid and sperm nuclear DNA, contributing to paternally transmitted diseases. ROS generation has a central role in the pathophysiology of age-related decrease in male fertility. 2010 Elsevier Inc. All rights reserved.

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Year:  2009        PMID： 19616285     DOI： 10.1016/j.urology.2009.05.025

Source DB:  PubMed          Journal:  Urology        ISSN： 0090-4295            Impact factor:   2.649


  34 in total

1.  Protein modification as oxidative stress marker in normal and pathological human seminal plasma.

Authors:  Paola Piomboni; Anita Stendardi; Laura Gambera; Carla Tatone; Lamberto Coppola; Vincenzo De Leo; Riccardo Focarelli
Journal:  Redox Rep       Date:  2012-07-07       Impact factor: 4.412

Review 2.  Ignorance but not bliss: too little is known about the determinants of semen quality.

Authors:  W C L Ford
Journal:  Asian J Androl       Date:  2013-01-14       Impact factor: 3.285

Review 3.  The role of antioxidant therapy in the treatment of male infertility: an overview.

Authors:  Francesco Lombardo; Andrea Sansone; Francesco Romanelli; Donatella Paoli; Loredana Gandini; Andrea Lenzi
Journal:  Asian J Androl       Date:  2011-06-20       Impact factor: 3.285

4.  Age affects gene expression in mouse spermatogonial stem/progenitor cells.

Authors:  Maria Kokkinaki; Tin-Lap Lee; Zuping He; Jiji Jiang; Nady Golestaneh; Marie-Claude Hofmann; Wai-Yee Chan; Martin Dym
Journal:  Reproduction       Date:  2010-04-06       Impact factor: 3.906

5.  Low-dose testosterone treatment decreases oxidative damage in TM3 Leydig cells.

Authors:  Thomas I S Hwang; Tien-Ling Liao; Ji-Fan Lin; Yi-Chia Lin; Shu-Yu Lee; Yen-Chun Lai; Shu-Huei Kao
Journal:  Asian J Androl       Date:  2011-02-07       Impact factor: 3.285

6.  Reactive oxygen species in the internal spermatic and brachial veins of patients with varicocele-induced infertility.

Authors:  Chang Jin Yoon; Hyun Jun Park; Nam Cheol Park
Journal:  Korean J Urol       Date:  2010-05-19

7.  Sub-fertile sperm cells exemplify telomere dysfunction.

Authors:  Tal Biron-Shental; Amir Wiser; Anat Hershko-Klement; Ofer Markovitch; Aliza Amiel; Arie Berkovitch
Journal:  J Assist Reprod Genet       Date:  2017-09-13       Impact factor: 3.412

8.  Growing up or growing old? Cellular aging linked with testosterone reactivity to stress in youth.

Authors:  Stacy S Drury; Elizabeth A Shirtcliff; Andrew Shachet; Jenny Phan; Emily Mabile; Zoë H Brett; Michael Wren; Kyle Esteves; Katherine P Theall
Journal:  Am J Med Sci       Date:  2014-08       Impact factor: 2.378

Review 9.  Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.

Authors:  Ashok Agarwal; Reda Z Mahfouz; Rakesh K Sharma; Oli Sarkar; Devna Mangrola; Premendu P Mathur
Journal:  Reprod Biol Endocrinol       Date:  2009-12-05       Impact factor: 5.211

10.  Changes in Phenotypes and DNA Methylation of In Vitro Aging Sperm in Common Carp Cyprinus carpio.

Authors:  Yu Cheng; Pavlina Vechtova; Zoltan Fussy; Jan Sterba; Zuzana Linhartová; Marek Rodina; Vladimíra Tučková; David Gela; Azin Mohagheghi Samarin; Ievgen Lebeda; Miaomiao Xin; Songpei Zhang; Deepali Rahi; Otomar Linhart
Journal:  Int J Mol Sci       Date:  2021-05-31       Impact factor: 5.923
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