Literature DB >> 19616201

Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.

L E Pereira1, N Onlamoon, X Wang, R Wang, J Li, K A Reimann, F Villinger, K Pattanapanyasat, K Mori, A A Ansari.   

Abstract

Recent findings established that primary targets of HIV/SIV are lymphoid cells within the gastrointestinal (GI) tract. Focus has therefore shifted to T-cells expressing alpha(4)beta(7) integrin which facilitates trafficking to the GI tract via binding to MAdCAM-1. Approaches to better understand the role of alpha(4)beta(7)+ T-cells in HIV/SIV pathogenesis include their depletion or blockade of their synthesis, binding and/or homing capabilities in vivo. Such studies can ideally be conducted in rhesus macaques (RM), the non-human primate model of AIDS. Characterization of alpha(4)beta(7) expression on cell lineages in RM blood and GI tissues reveal low densities of expression by NK cells, B-cells, naïve and TEM (effector memory) T-cells. High densities were observed on TCM (central memory) T-cells. Intravenous administration of a single 50mg/kg dose of recombinant rhesus alpha(4)beta(7) antibody resulted in significant initial decline of alpha(4)beta(7)+ lymphocytes and sustained coating of the alpha(4)beta(7) receptor in both the periphery and GI tissues.

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Year:  2009        PMID： 19616201      PMCID： PMC2765715          DOI： 10.1016/j.cellimm.2009.06.012

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  45 in total

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Journal:  Gastroenterology       Date:  1999-05       Impact factor: 22.682

2.  Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo.

Authors:  R S Veazey; I C Tham; K G Mansfield; M DeMaria; A E Forand; D E Shvetz; L V Chalifoux; P K Sehgal; A A Lackner
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

3.  Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin.

Authors:  Brian G Feagan; Gordon R Greenberg; Gary Wild; Richard N Fedorak; Pierre Paré; John W D McDonald; Rejean Dubé; Albert Cohen; A Hillary Steinhart; Steven Landau; Rasha A Aguzzi; Irving H Fox; Margaret K Vandervoort
Journal:  N Engl J Med       Date:  2005-06-16       Impact factor: 91.245

Review 4.  T-cell recruitment to the intestinal mucosa.

Authors:  William W Agace
Journal:  Trends Immunol       Date:  2008-11       Impact factor: 16.687

5.  Rapid turnover of T lymphocytes in SIV-infected rhesus macaques.

Authors:  H Mohri; S Bonhoeffer; S Monard; A S Perelson; D D Ho
Journal:  Science       Date:  1998-02-20       Impact factor: 47.728

6.  Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts.

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Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

7.  Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.

Authors:  R S Veazey; M DeMaria; L V Chalifoux; D E Shvetz; D R Pauley; H L Knight; M Rosenzweig; R P Johnson; R C Desrosiers; A A Lackner
Journal:  Science       Date:  1998-04-17       Impact factor: 47.728

8.  l-selectin and alpha4beta7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice.

Authors:  Shannon R Reese; Kenneth A Kudsk; Laurence Genton; Shigeo Ikeda
Journal:  Surgery       Date:  2005-02       Impact factor: 3.982

9.  Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques.

Authors:  A Kaur; R M Grant; R E Means; H McClure; M Feinberg; R P Johnson
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

10.  Integrin alpha 4 beta 7 co-stimulation of human peripheral blood T cell proliferation.

Authors:  T K Teague; A I Lazarovits; B W McIntyre
Journal:  Cell Adhes Commun       Date:  1994-12
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  16 in total

1.  Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Authors:  Maren Q DeGottardi; Afam A Okoye; Mukta Vaidya; Aarthi Talla; Audrie L Konfe; Matthew D Reyes; Joseph A Clock; Derick M Duell; Alfred W Legasse; Amit Sabnis; Byung S Park; Michael K Axthelm; Jacob D Estes; Keith A Reiman; Rafick-Pierre Sekaly; Louis J Picker
Journal:  J Immunol       Date:  2016-07-18       Impact factor: 5.422

2.  Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

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3.  Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques.

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Journal:  Blood       Date:  2011-06-21       Impact factor: 22.113

4.  Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.

Authors:  Aftab A Ansari; Keith A Reimann; Ann E Mayne; Yoshiaki Takahashi; Susan T Stephenson; Rijian Wang; Xinyue Wang; Jichu Li; Andrew A Price; Dawn M Little; Mohammad Zaidi; Robert Lyles; Francois Villinger
Journal:  J Immunol       Date:  2010-12-13       Impact factor: 5.422

5.  Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56+ NK cells.

Authors:  R Keith Reeves; Tristan I Evans; Jacqueline Gillis; R Paul Johnson
Journal:  J Virol       Date:  2010-06-16       Impact factor: 5.103

6.  T Cells in the Female Reproductive Tract Can Both Block and Facilitate HIV Transmission.

Authors:  Christopher J Miller; Ronald S Veazey
Journal:  Curr Immunol Rev       Date:  2019

7.  Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.

Authors:  Ines Frank; Mariasole Cigoli; Muhammad S Arif; Marissa D Fahlberg; Stephanie Maldonado; Giulia Calenda; Amarendra Pegu; Eun Sung Yang; Reda Rawi; Gwo-Yu Chuang; Hui Geng; Cuiping Liu; Tongqing Zhou; Peter D Kwong; James Arthos; Claudia Cicala; Brooke F Grasperge; James L Blanchard; Agegnehu Gettie; Christine M Fennessey; Brandon F Keele; Monica Vaccari; Thomas J Hope; Anthony S Fauci; John R Mascola; Elena Martinelli
Journal:  Sci Transl Med       Date:  2021-08-18       Impact factor: 19.319

8.  Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques.

Authors:  Giulia Calenda; Rassamon Keawvichit; Géraldine Arrode-Brusés; Kovit Pattanapanyasat; Ines Frank; Siddappa N Byrareddy; James Arthos; Claudia Cicala; Brooke Grasperge; James L Blanchard; Agegnehu Gettie; Keith A Reimann; Aftab A Ansari; Elena Martinelli
Journal:  J Immunol       Date:  2017-12-01       Impact factor: 5.422

9.  Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy.

Authors:  Chad R Wells; Youfang Cao; David P Durham; Siddappa N Byrareddy; Aftab A Ansari; Nancy H Ruddle; Jeffrey P Townsend; Alison P Galvani; Alan S Perelson
Journal:  PLoS Comput Biol       Date:  2021-06-09       Impact factor: 4.475

10.  Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

Authors:  Siddappa N Byrareddy; Brianne Kallam; James Arthos; Claudia Cicala; Fatima Nawaz; Joseph Hiatt; Ellen N Kersh; Janet M McNicholl; Debra Hanson; Keith A Reimann; Markus Brameier; Lutz Walter; Kenneth Rogers; Ann E Mayne; Paul Dunbar; Tara Villinger; Dawn Little; Tristram G Parslow; Philip J Santangelo; Francois Villinger; Anthony S Fauci; Aftab A Ansari
Journal:  Nat Med       Date:  2014-11-24       Impact factor: 53.440
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