| Literature DB >> 19616097 |
Zeyu Liu1, Zhongmin Guo, Guoling Wang, Dingmei Zhang, Hongxuan He, Guowei Li, Yuge Liu, Denise Higgins, Aoiffe Walsh, Leo Shanahan-Prendergast, Jiahai Lu.
Abstract
The development of novel antiviral drugs is necessary for the prevention and treatment of a potential avian influenza pandemic. The aim of this study was to evaluate the efficacy and safety of a novel statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in a murine model. In H5N1-, H3N2- and H1N1-infected BALB/c mice, 50mug statin/200mug caffeine effectively ameliorated lung damage and inhibited viral replication and was at least as effective as oseltamivir and ribavirin. The statin/caffeine combination also appeared to be more effective when administered preventatively rather than as treatment. These findings provide justification for further research into this novel antiviral formulation.Entities:
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Year: 2009 PMID： 19616097 DOI： 10.1016/j.ejps.2009.07.004
Source DB: PubMed Journal: Eur J Pharm Sci ISSN： 0928-0987 Impact factor: 4.384