Literature DB >> 19615366

Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice.

Matthias Schilling1, Jan-Kolja Strecker, E Bernd Ringelstein, Reinhard Kiefer, Wolf-Rüdiger Schäbitz.   

Abstract

Perivascular and meningeal macrophages are important for immune surveillance in the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage migration and permeability of the blood brain barrier. In the present study, we investigated the influence of MCP-1 or/and chemokine receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice revealed a virtual absence of blood-borne macrophage recruitment. This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions.

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Year:  2009        PMID： 19615366     DOI： 10.1016/j.expneurol.2009.07.003

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  12 in total

1.  Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.

Authors:  Honghong Yao; Yanjing Yang; Kee Jun Kim; Crystal Bethel-Brown; Nan Gong; Keiko Funa; Howard E Gendelman; Tsung-Ping Su; John Q Wang; Shilpa Buch
Journal:  Blood       Date:  2010-03-30       Impact factor: 22.113

Review 2.  Rodent models of HAND and drug abuse: exogenous administration of viral protein(s) and cocaine.

Authors:  Honghong Yao; Shilpa Buch
Journal:  J Neuroimmune Pharmacol       Date:  2012-03-24       Impact factor: 4.147

Review 3.  Inflammation and Stroke: An Overview.

Authors:  Josef Anrather; Costantino Iadecola
Journal:  Neurotherapeutics       Date:  2016-10       Impact factor: 7.620

4.  Cocaine hijacks σ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS.

Authors:  Honghong Yao; Keejun Kim; Ming Duan; Teruo Hayashi; Minglei Guo; Susan Morgello; Alexander Prat; John Wang; Tsung-Ping Su; Shilpa Buch
Journal:  J Neurosci       Date:  2011-04-20       Impact factor: 6.167

Review 5.  Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

Authors:  Annette D de Kloet; Eric G Krause; Peng D Shi; Jasenka Zubcevic; Mohan K Raizada; Colin Sumners
Journal:  Pharmacol Ther       Date:  2013-02-28       Impact factor: 12.310

6.  Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy.

Authors:  Natalie M Zahr; Carsten Alt; Dirk Mayer; Torsten Rohlfing; Amy Manning-Bog; Richard Luong; Edith V Sullivan; Adolf Pfefferbaum
Journal:  Exp Neurol       Date:  2014-06-25       Impact factor: 5.330

Review 7.  Macrophages at CNS interfaces: ontogeny and function in health and disease.

Authors:  Katrin Kierdorf; Takahiro Masuda; Marta Joana Costa Jordão; Marco Prinz
Journal:  Nat Rev Neurosci       Date:  2019-07-29       Impact factor: 34.870

Review 8.  The immunology of stroke: from mechanisms to translation.

Authors:  Costantino Iadecola; Josef Anrather
Journal:  Nat Med       Date:  2011-07-07       Impact factor: 53.440

9.  Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media.

Authors:  Jeong-Im Woo; Huiqi Pan; Sejo Oh; David J Lim; Sung K Moon
Journal:  BMC Infect Dis       Date:  2010-10-28       Impact factor: 3.090

10.  Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.

Authors:  Pranay Srivastava; Chunxia G Cronin; Victoria L Scranton; Kenneth A Jacobson; Bruce T Liang; Rajkumar Verma
Journal:  Exp Neurol       Date:  2020-04-11       Impact factor: 5.330
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