BACKGROUND: As presented in the introduction paper, three sets of differentially regulated genes were found after the analysis of the chicken infection data set from EADGENE. Different methods were used to interpret these results. RESULTS: GOTM, Pathway Studio and Ingenuity softwares were used to investigate the three lists of genes. The three softwares allowed the analysis of the data and highlighted different networks. However, only one set of genes, showing a differential expression between primary and secondary response gave significant biological interpretation. CONCLUSION: Combining these databases that were developed independently on different annotation sources supplies a useful tool for a global biological interpretation of microarray data, even if they may contain some imperfections (e.g. gene not or not well annotated).
BACKGROUND: As presented in the introduction paper, three sets of differentially regulated genes were found after the analysis of the chicken infection data set from EADGENE. Different methods were used to interpret these results. RESULTS: GOTM, Pathway Studio and Ingenuity softwares were used to investigate the three lists of genes. The three softwares allowed the analysis of the data and highlighted different networks. However, only one set of genes, showing a differential expression between primary and secondary response gave significant biological interpretation. CONCLUSION: Combining these databases that were developed independently on different annotation sources supplies a useful tool for a global biological interpretation of microarray data, even if they may contain some imperfections (e.g. gene not or not well annotated).
Authors: M Ashburner; C A Ball; J A Blake; D Botstein; H Butler; J M Cherry; A P Davis; K Dolinski; S S Dwight; J T Eppig; M A Harris; D P Hill; L Issel-Tarver; A Kasarskis; S Lewis; J C Matese; J E Richardson; M Ringwald; G M Rubin; G Sherlock Journal: Nat Genet Date: 2000-05 Impact factor: 38.330
Authors: Cristina Arce; Silvio Bicciato; Agnès Bonnet; Bart Buitenhuis; Melania Collado-Romero; Lene N Conley; Magali SanCristobal; Francesco Ferrari; Juan J Garrido; Martien Am Groenen; Henrik Hornshøj; Ina Hulsegge; Li Jiang; Ángeles Jiménez-Marín; Arun Kommadath; Sandrine Lagarrigue; Jack Am Leunissen; Laurence Liaubet; Pieter Bt Neerincx; Haisheng Nie; Jan van der Poel; Dennis Prickett; María Ramirez-Boo; Johanna Mj Rebel; Christèle Robert-Granié; Axel Skarman; Mari A Smits; Peter Sørensen; Gwenola Tosser-Klopp; Michael Watson; Jakob Hedegaard Journal: BMC Proc Date: 2009-07-16
Authors: Cristina Arce; Silvio Bicciato; Agnès Bonnet; Bart Buitenhuis; Melania Collado-Romero; Lene N Conley; Magali SanCristobal; Francesco Ferrari; Juan J Garrido; Martien Am Groenen; Henrik Hornshøj; Ina Hulsegge; Li Jiang; Ángeles Jiménez-Marín; Arun Kommadath; Sandrine Lagarrigue; Jack Am Leunissen; Laurence Liaubet; Pieter Bt Neerincx; Haisheng Nie; Jan van der Poel; Dennis Prickett; María Ramirez-Boo; Johanna Mj Rebel; Christèle Robert-Granié; Axel Skarman; Mari A Smits; Peter Sørensen; Gwenola Tosser-Klopp; Michael Watson; Jakob Hedegaard Journal: BMC Proc Date: 2009-07-16