Literature DB >> 19610601

A short, economical synthesis of 2-methoxyestradiol, an anticancer agent in clinical trials.

Yuqing Hou1, Cal Y Meyers, Mercy Akomeah.   

Abstract

2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl peroxide.

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Year:  2009        PMID： 19610601     DOI： 10.1021/jo901086s

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

Review 1.  Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia.

Authors:  Alejandra Perez-Sepulveda; Pedro P España-Perrot; Errol R Norwitz; Sebastián E Illanes
Journal:  Reprod Sci       Date:  2013-03-01       Impact factor: 3.060

2.  Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives.

Authors:  Qi Wan; Yan Deng; Yaoqing Huang; Zhihui Yu; Chunli Wang; Ke Wang; Jibin Dong; Ying Chen
Journal:  ChemistryOpen       Date:  2019-12-11       Impact factor: 2.911

3.  2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells.

Authors:  Kuan-Lin Kuo; Wei-Chou Lin; I-Lin Ho; Hong-Chiang Chang; Ping-Yi Lee; Yuan-Ting Chung; Ju-Ton Hsieh; Yeong-Shiau Pu; Chung-Sheng Shi; Kuo-How Huang
Journal:  PLoS One       Date:  2013-08-13       Impact factor: 3.240

4.  Oxacycle synthesis via intramolecular reaction of carbanions and peroxides.

Authors:  Rachel Willand-Charnley; Benjamin W Puffer; Patrick H Dussault
Journal:  J Am Chem Soc       Date:  2014-04-09       Impact factor: 15.419

5.  Synthesis of Ethers via Reaction of Carbanions and Monoperoxyacetals.

Authors:  ShivaKumar Kyasa; Rebecca N Meier; Ruth A Pardini; Tristan K Truttmann; Keith T Kuwata; Patrick H Dussault
Journal:  J Org Chem       Date:  2015-12-07       Impact factor: 4.354
  5 in total

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