RATIONALE: Chronic obstructive pulmonary disease (COPD) is a complex disorder with high mortality worldwide. Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results. OBJECTIVES: The aim of this study was to reveal the role of COPD candidate genes using data collected in previous research. METHODS: We performed meta-analyses on 20 polymorphisms in 12 genes, after searching the PubMed and Embase databases for publications on COPD. These genes involve three main pathways associated with COPD development: the inflammatory, protease-antiprotease balance, and antioxidant pathways. MEASUREMENTS AND MAIN RESULTS: We obtained significant results for three TGFB1 polymorphisms, although these were based only on a few studies. The IL1RN VNTR polymorphism increases the risk for COPD (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.09-2.65), whereas the TNFA -308 G/A polymorphism does so only in Asian populations (OR, 2.01; 95% CI, 1.21-3.31). The GSTP1 I105V polymorphism was protective for COPD in Asian populations only (OR, 0.69; 95% CI, 0.56-0.85). CONCLUSIONS: These results demonstrate the importance of ethnicity in identifying specific COPD genes.
RATIONALE: Chronic obstructive pulmonary disease (COPD) is a complex disorder with high mortality worldwide. Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results. OBJECTIVES: The aim of this study was to reveal the role of COPD candidate genes using data collected in previous research. METHODS: We performed meta-analyses on 20 polymorphisms in 12 genes, after searching the PubMed and Embase databases for publications on COPD. These genes involve three main pathways associated with COPD development: the inflammatory, protease-antiprotease balance, and antioxidant pathways. MEASUREMENTS AND MAIN RESULTS: We obtained significant results for three TGFB1 polymorphisms, although these were based only on a few studies. The IL1RN VNTR polymorphism increases the risk for COPD (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.09-2.65), whereas the TNFA-308 G/A polymorphism does so only in Asian populations (OR, 2.01; 95% CI, 1.21-3.31). The GSTP1I105V polymorphism was protective for COPD in Asian populations only (OR, 0.69; 95% CI, 0.56-0.85). CONCLUSIONS: These results demonstrate the importance of ethnicity in identifying specific COPD genes.
Authors: Peter J Castaldi; Michael H Cho; Matthew Cohn; Fawn Langerman; Sienna Moran; Nestor Tarragona; Hala Moukhachen; Radhika Venugopal; Delvina Hasimja; Esther Kao; Byron Wallace; Craig P Hersh; Sachin Bagade; Lars Bertram; Edwin K Silverman; Thomas A Trikalinos Journal: Hum Mol Genet Date: 2009-11-20 Impact factor: 6.150
Authors: Emily A Vucic; Raj Chari; Kelsie L Thu; Ian M Wilson; Allison M Cotton; Jennifer Y Kennett; May Zhang; Kim M Lonergan; Katrina Steiling; Carolyn J Brown; Annette McWilliams; Keishi Ohtani; Marc E Lenburg; Don D Sin; Avrum Spira; Calum E Macaulay; Stephen Lam; Wan L Lam Journal: Am J Respir Cell Mol Biol Date: 2014-05 Impact factor: 6.914
Authors: Joanna Smolonska; Gerard H Koppelman; Cisca Wijmenga; Judith M Vonk; Pieter Zanen; Marcel Bruinenberg; Ivan Curjuric; Medea Imboden; Gian-Andri Thun; Lude Franke; Nicole M Probst-Hensch; Peter Nürnberg; Roland A Riemersma; Constant P van Schayck; Daan W Loth; Guy G Brusselle; Bruno H Stricker; Albert Hofman; André G Uitterlinden; Lies Lahousse; Stephanie J London; Laura R Loehr; Ani Manichaikul; R Graham Barr; Kathleen M Donohue; Stephen S Rich; Peter Pare; Yohan Bossé; Ke Hao; Maarten van den Berge; Harry J M Groen; Jan-Willem J Lammers; Willem Mali; H Marike Boezen; Dirkje S Postma Journal: Eur Respir J Date: 2014-07-03 Impact factor: 16.671