ETHNOPHARMACOLOGICAL RELEVANCE: Plectranthus amboinicus (Lour.) Spreng is a medicinal specie often used in Brazil, especially in Northeast Region, for the treatment of several diseases including inflammations and cancer. AIM OF THE STUDY: To evaluate the anti-inflammatory and antitumor activities of the hydroalcoholic extract from leaves of P. amboinicus in an attempt to determine whether the medicinal uses are supported by pharmacological effects. MATERIALS AND METHODS: Anti-inflammatory activity was determined by carrageenan-induced paw edema method. The antitumor effect was evaluated in an in vivo experimental study, using the following tumors: Sarcoma-180 and Erlich ascite carcinoma. RESULTS: There were statistically significant decreases (p<.05) of edema paw in at the doses of 150, 250 and 350 mg/kg (i.p.) of the hydroalcoholic extract of P. amboinicus. Similarly, the administration of P. amboinicus at the doses of 100, 150, 250 and 350 mg/kg (i.p.) inhibited the growth of sarcoma-180 and Ehrlich ascite carcinoma tumors in mice. CONCLUSION: The results suggest that the hydroalcoholic extract of P. amboinicus possesses anti-inflammatory and antitumor activities, supporting the folk use of this medicinal specie.
ETHNOPHARMACOLOGICAL RELEVANCE: Plectranthus amboinicus (Lour.) Spreng is a medicinal specie often used in Brazil, especially in Northeast Region, for the treatment of several diseases including inflammations and cancer. AIM OF THE STUDY: To evaluate the anti-inflammatory and antitumor activities of the hydroalcoholic extract from leaves of P. amboinicus in an attempt to determine whether the medicinal uses are supported by pharmacological effects. MATERIALS AND METHODS: Anti-inflammatory activity was determined by carrageenan-induced paw edema method. The antitumor effect was evaluated in an in vivo experimental study, using the following tumors: Sarcoma-180 and Erlich ascite carcinoma. RESULTS: There were statistically significant decreases (p<.05) of edema paw in at the doses of 150, 250 and 350 mg/kg (i.p.) of the hydroalcoholic extract of P. amboinicus. Similarly, the administration of P. amboinicus at the doses of 100, 150, 250 and 350 mg/kg (i.p.) inhibited the growth of sarcoma-180 and Ehrlich ascite carcinoma tumors in mice. CONCLUSION: The results suggest that the hydroalcoholic extract of P. amboinicus possesses anti-inflammatory and antitumor activities, supporting the folk use of this medicinal specie.
Authors: Francisco Fábio Martins de Oliveira; Alba Fabiola Torres; Thially Braga Gonçalves; Gilvandete Maria Pinheiro Santiago; Cibele Barreto Mano de Carvalho; Milena Braga Aguiar; Lilia Maria Carneiro Camara; Silvia Helena Rabenhorst; Alice Maria Costa Martins; José Telmo Valença Junior; Aparecida Tiemi Nagao-Dias Journal: Evid Based Complement Alternat Med Date: 2013-02-20 Impact factor: 2.629
Authors: Eduardo M Brandao; Paulo H D M Brandão; Ivone A Souza; Gerson S Paiva; Marcos de C Carvalho; Claudio M Lacerda Journal: J Cancer Date: 2013-08-20 Impact factor: 4.207
Authors: Silvio César Gomes de Lima; Maria Jania Teixeira; José Evaldo Gonçalves Lopes; Selene Maia de Morais; Alba Fabiola Torres; Milena Aguiar Braga; Raphael Oliveira Rodrigues; Gilvandete Maria Pinheiro Santiago; Alice Costa Martins; Aparecida Tiemi Nagao-Dias Journal: Biomed Res Int Date: 2014-04-16 Impact factor: 3.411