AIM OF THE STUDY: This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. MATERIALS AND METHODS: The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study. RESULTS: Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg). CONCLUSIONS: Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.
AIM OF THE STUDY: This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. MATERIALS AND METHODS: The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study. RESULTS: Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mousepain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouseear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg). CONCLUSIONS:Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.
Authors: M Nyalambisa; I A Oyemitan; R Matewu; O O Oyedeji; O S Oluwafemi; S P Songca; B N Nkeh-Chungag; A O Oyedeji Journal: Saudi Pharm J Date: 2016-09-30 Impact factor: 4.330