| Literature DB >> 19606870 |
Helen J Mitchell1, William P Dankulich, George D Hartman, Thomayant Prueksaritanont, Azriel Schmidt, Robert L Vogel, Chang Bai, Sheila McElwee-Witmer, Hai Z Zhang, Fang Chen, Chih-Tai Leu, Donald B Kimmel, William J Ray, Pascale Nantermet, Michael A Gentile, Mark E Duggan, Robert S Meissner.
Abstract
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in dogs. On the basis of its in vitro profile, 21 was evaluated in the OVX and ORX rat models and exhibited an osteoanabolic, tissue-selective profile.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19606870 DOI： 10.1021/jm900880r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446