Phenethyl-alpha-pyrone derivatives and cyclodipeptides from a marine algous endophytic fungus Aspergillus niger EN-13.

Two new phenethyl-alpha-pyrone derivatives including, isopyrophen (1) and aspergillusol (2), were characterised from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the inner tissue of the marine brown alga Colpomenia sinuosa. In addition, four known compounds, including a phenethyl-alpha-pyrone derivative (pyrophen, 3) and three cyclodipeptides (4-6), were also isolated and identified. The structures of these compounds were elucidated by spectroscopic methods.