| Literature DB >> 19604877 |
M Godschalk1, M R Dzoljic, I L Bonta.
Abstract
Administration of gamma-hydroxybutyrate (GHB) (200 mg/kg i.p.) in rats evoked a hypersynchronous electrocorticogram pattern which was antagonized by specific anti-petit mal agents, while other antiepileptic drugs exerted no influence, or even potentiated the effect of GHB. The specific sensitivity of the GHB-induced hypersynchrony to anti-petit mal agents suggests a possible use of this effect as a model for testing potential anti-petit mal agents.Entities:
Year: 1976 PMID： 19604877 DOI： 10.1016/0304-3940(76)90084-7
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046