The effect of glucose on the activity of the adrenal nerve and pancreatic branch of the vagus nerve in the rabbit.

Efferent discharges were recorded from nerve filaments dissected from the adrenal branch of the splanchnic nerve and pancreatic branch of the vagus nerve. Infusion of glucose into the carotid artery caused a decrease in discharge rate of adrenal nerve and an increase of it in the pancreatic branch of the vagus nerve. No change in activity in both nerve branches was observed following infusion of mannose. An i.v. injection of glucose showed smaller effects. Glucose-sensitive neurons in the hypothalamus may play a role in these responses.