| Literature DB >> 19604486 |
Mohamed Lamkanfi1, Vishva M Dixit.
Abstract
The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.Entities:
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Year: 2009 PMID： 19604486 DOI： 10.1016/j.immuni.2009.06.011
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745