Literature DB >> 19604079

Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.

Alvin Gomez1, Magnus Ingelman-Sundberg.   

Abstract

Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response.

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Year:  2009        PMID： 19604079     DOI： 10.2217/pgs.09.56

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  17 in total

1.  Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9.

Authors:  Neal A Englert; George Luo; Joyce A Goldstein; Sailesh Surapureddi
Journal:  J Biol Chem       Date:  2014-11-12       Impact factor: 5.157

2.  Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport.

Authors:  Magnus Ingelman-Sundberg; Xiao-Bo Zhong; Oliver Hankinson; Sudheer Beedanagari; Ai-Ming Yu; Lai Peng; Yoichi Osawa
Journal:  Drug Metab Dispos       Date:  2013-08-05       Impact factor: 3.922

3.  Effective classification of microRNA precursors using feature mining and AdaBoost algorithms.

Authors:  Ling Zhong; Jason T L Wang; Dongrong Wen; Virginie Aris; Patricia Soteropoulos; Bruce A Shapiro
Journal:  OMICS       Date:  2013-06-29

Review 4.  Cytochrome P450-mediated drug metabolism in the brain.

Authors:  Sharon Miksys; Rachel F Tyndale
Journal:  J Psychiatry Neurosci       Date:  2013-05       Impact factor: 6.186

5.  Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells.

Authors:  Liming Chen; Pei Wang; José E Manautou; Xiao-Bo Zhong
Journal:  Mol Pharmacol       Date:  2020-02-06       Impact factor: 4.436

6.  MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.

Authors:  Alice C Rodrigues; Xin Li; Laura Radecki; Yu-Zhuo Pan; Jerrold C Winter; Min Huang; Ai-Ming Yu
Journal:  Biopharm Drug Dispos       Date:  2011-07-28       Impact factor: 1.627

Review 7.  MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.

Authors:  Stephanie Ceman; Julie Saugstad
Journal:  Pharmacol Ther       Date:  2011-01-20       Impact factor: 12.310

Review 8.  The emerging role of microRNAs in drug responses.

Authors:  Wei Zhang; M Eileen Dolan
Journal:  Curr Opin Mol Ther       Date:  2010-12

9.  Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells.

Authors:  Xin Li; Yu-Zhuo Pan; Gail M Seigel; Zi-Hua Hu; Min Huang; Ai-Ming Yu
Journal:  Biochem Pharmacol       Date:  2011-01-08       Impact factor: 5.858

10.  Noncoding microRNAs: small RNAs play a big role in regulation of ADME?

Authors:  Ai-Ming Yu; Yu-Zhuo Pan
Journal:  Acta Pharm Sin B       Date:  2012-03-31       Impact factor: 11.413
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