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Literature DB >> 19602654

Use of dexamethasone and prednisone in acute asthma exacerbations in pediatric patients.

Abstract

QUESTION: Children frequently present to my rural emergency department with asthma exacerbations. Should I prescribe systemic corticosteroids? If so, which systemic corticosteroid should I prescribe? ANSWER: A short course of steroids is indicated in the treatment of asthma exacerbations. Both prednisone (1 to 2 mg/kg daily for 5 days) and dexamethasone (0.3 to 0.6 mg/kg daily for 1 to 5 days) are effective in reducing hospital admissions and unscheduled return to care, with minimal side effects.

Entities: Chemical Disease Species

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Year: 2009 PMID： 19602654 PMCID： PMC2718595

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

14 in total

Review 1. Early emergency department treatment of acute asthma with systemic corticosteroids.

Authors: B H Rowe; C Spooner; F M Ducharme; J A Bretzlaff; G W Bota
Journal: Cochrane Database Syst Rev Date: 2001

2. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma.

Authors: F Qureshi; A Zaritsky; M P Poirier
Journal: J Pediatr Date: 2001-07 Impact factor: 4.406

3. Canadian Pediatric Asthma Consensus guidelines, 2003 (updated to December 2004): introduction.

Authors: Allan Becker; Denis Bérubé; Zave Chad; Myrna Dolovich; Francine Ducharme; Tony D'Urzo; Pierre Ernst; Alexander Ferguson; Cathy Gillespie; Sandeep Kapur; Tom Kovesi; Brian Lyttle; Bruce Mazer; Mark Montgomery; Soren Pedersen; Paul Pianosi; John Joseph Reisman; Malcolm Sears; Estelle Simons; Sheldon Spier; Robert Thivierge; Wade Watson; Barry Zimmerman
Journal: CMAJ Date: 2005-09-13 Impact factor: 8.262

Review 4. The mechanism of action of corticosteroids in asthma.

Authors: I K Taylor; R J Shaw
Journal: Respir Med Date: 1993-05 Impact factor: 3.415

5. Oral versus intravenous corticosteroids in children hospitalized with asthma.

Authors: J M Becker; A Arora; R J Scarfone; N D Spector; M E Fontana-Penn; E Gracely; M D Joffe; D P Goldsmith; J J Malatack
Journal: J Allergy Clin Immunol Date: 1999-04 Impact factor: 10.793

6. Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial.

Authors: A Tal; N Levy; J E Bearman
Journal: Pediatrics Date: 1990-09 Impact factor: 7.124

7. Asthma attack periodicity: a study of hospital emergency visits in Vancouver.

Authors: D V Bates; M Baker-Anderson; R Sizto
Journal: Environ Res Date: 1990-02 Impact factor: 6.498

8. A controlled trial of methylprednisolone in the emergency treatment of acute asthma.

Authors: B Littenberg; E H Gluck
Journal: N Engl J Med Date: 1986-01-16 Impact factor: 91.245

9. A comparison of oral dexamethasone with oral prednisone in pediatric asthma exacerbations treated in the emergency department.

Authors: Richard A Greenberg; Gwen Kerby; Genie E Roosevelt
Journal: Clin Pediatr (Phila) Date: 2008-05-08 Impact factor: 1.168

10. Safety profile of frequent short courses of oral glucocorticoids in acute pediatric asthma: impact on bone metabolism, bone density, and adrenal function.

Authors: Francine M Ducharme; Gilles Chabot; Constantin Polychronakos; Francis Glorieux; Bruce Mazer
Journal: Pediatrics Date: 2003-02 Impact factor: 7.124

14 in total

1. Implications of combined ovariectomy and glucocorticoid (dexamethasone) treatment on mineral, microarchitectural, biomechanical and matrix properties of rat bone.

Authors: Parameswari Govindarajan; Thaqif Khassawna; Marian Kampschulte; Wolfgang Böcker; Britta Huerter; Lutz Dürselen; Miriam Faulenbach; Christian Heiss
Journal: Int J Exp Pathol Date: 2013-09-02 Impact factor: 1.925

2. Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper.

Authors: Francine M Ducharme; Sharon D Dell; Dhenduka Radhakrishnan; Roland M Grad; Wade T A Watson; Connie L Yang; Mitchell Zelman
Journal: Can Respir J Date: 2015-04-20 Impact factor: 2.409

3. Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.

Authors: Heung-Woo Park; Bing Ge; Szeman Tse; Elin Grundberg; Tomi Pastinen; H William Kelly; Kelan G Tantisira
Journal: J Allergy Clin Immunol Date: 2015-05-27 Impact factor: 10.793

4. Controlled Bioactive Delivery Using Degradable Electroactive Polymers.

Authors: Mark D Ashton; Patricia A Cooper; Sofia Municoy; Martin F Desimone; David Cheneler; Steven D Shnyder; John G Hardy
Journal: Biomacromolecules Date: 2022-06-24 Impact factor: 6.978

5. Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper.

Authors: Francine M Ducharme; Sharon D Dell; Dhenuka Radhakrishnan; Roland M Grad; Wade Ta Watson; Connie L Yang; Mitchell Zelman
Journal: Paediatr Child Health Date: 2015-10 Impact factor: 2.253

Review 6. The Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19.

Authors: Heloísa Antoniella Braz-de-Melo; Sara Socorro Faria; Gabriel Pasquarelli-do-Nascimento; Igor de Oliveira Santos; Gary P Kobinger; Kelly Grace Magalhães
Journal: Front Med (Lausanne) Date: 2021-04-23

7. Stress induced Salmonella Typhimurium recrudescence in pigs coincides with cortisol induced increased intracellular proliferation in macrophages.

Authors: Elin Verbrugghe; Filip Boyen; Alexander Van Parys; Kim Van Deun; Siska Croubels; Arthur Thompson; Neil Shearer; Bregje Leyman; Freddy Haesebrouck; Frank Pasmans
Journal: Vet Res Date: 2011-12-07 Impact factor: 3.683