Literature DB >> 19601873

A comparative study on the stability of silybin and that in silymarin in buffers and biological fluids.

Ning Tang1, Danni Wu, Yi Lu, Jian Chen, Bei Zhang, Wei Wu.   

Abstract

Pure silybin was found to be unstable whilst silybin in silymarin was stable in buffers from pH 1.0 to 7.8. The metabolism of silybin was more severe when in its pure form as compared to silybin in silymarin, as tested in a range of biological fluids including plasma, intestinal fluid and liver homogenates. It would appear that components in silymarin have a stabilization effect on its main component silybin.

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Year:  2009        PMID: 19601873     DOI: 10.2174/187231209788654072

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN: 1872-3128


  2 in total

Review 1.  Silybin and the liver: from basic research to clinical practice.

Authors:  Carmela Loguercio; Davide Festi
Journal:  World J Gastroenterol       Date:  2011-05-14       Impact factor: 5.742

Review 2.  Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives.

Authors:  Peter F Surai
Journal:  Antioxidants (Basel)       Date:  2015-03-20
  2 in total

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