Literature DB >> 1960149

Origin of chromosome rearrangements in two long-lived human keratinocyte lines.

C Rosenberg1, G Stetten, W G Kearns, P L Pearson, J W Littlefield.   

Abstract

We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.

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Year:  1991        PMID： 1960149     DOI： 10.1007/bf02631249

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  9 in total

Review 1.  Chromosome translocations in human cancer.

Authors:  J R Testa
Journal:  Cell Growth Differ       Date:  1990-02

2.  Partial trisomies in two spontaneously arising long-lived human keratinocyte lines.

Authors:  J D Weaver; G Stetten; J W Littlefield
Journal:  In Vitro Cell Dev Biol       Date:  1991-08

3.  Immortal clones of NM1 keratinocytes contain an isochromosome of the long arm of chromosome 8.

Authors:  M L Goldaber; J Kubilus; S B Phillips; C Henkle; L Atkins; H P Baden
Journal:  In Vitro Cell Dev Biol       Date:  1990-01

Review 4.  A genetic model for colorectal tumorigenesis.

Authors:  E R Fearon; B Vogelstein
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

5.  Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Authors:  D Pinkel; J Landegent; C Collins; J Fuscoe; R Segraves; J Lucas; J Gray
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

6.  A simple method of reducing the fading of immunofluorescence during microscopy.

Authors:  G D Johnson; G M Nogueira Araujo
Journal:  J Immunol Methods       Date:  1981       Impact factor: 2.303

7.  Spontaneous establishment and characterization of mouse keratinocyte cell lines in serum-free medium.

Authors:  M E Kaighn; R F Camalier; F Bertolero; U Saffiotti
Journal:  In Vitro Cell Dev Biol       Date:  1988-08

8.  Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1).

Authors:  H P Baden; J Kubilus; J C Kvedar; M L Steinberg; S R Wolman
Journal:  In Vitro Cell Dev Biol       Date:  1987-03

9.  Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

Authors:  P Boukamp; R T Petrussevska; D Breitkreutz; J Hornung; A Markham; N E Fusenig
Journal:  J Cell Biol       Date:  1988-03       Impact factor: 10.539
  9 in total
  2 in total

Review 1.  A free-radical hypothesis for the instability and evolution of genotype and phenotype in vitro.

Authors:  R E Parchment; K Natarajan
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

2.  Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes.

Authors:  R H Rice; K E Steinmann; L A deGraffenried; Q Qin; N Taylor; R Schlegel
Journal:  Mol Biol Cell       Date:  1993-02       Impact factor: 4.138
  2 in total

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