Literature DB >> 19597787

Kinetic modeling as a tool to integrate multilevel dynamic experimental data.

Ekaterina Mogilevskaya1, Natalia Bagrova, Tatiana Plyusnina, Nail Gizzatkulov, Eugeniy Metelkin, Ekaterina Goryacheva, Sergey Smirnov, Yuriy Kosinsky, Aleksander Dorodnov, Kirill Peskov, Tatiana Karelina, Igor Goryanin, Oleg Demin.   

Abstract

The metabolic networks are the most well-studied biochemical systems, with an abundance of in vitro and in vivo data available for quantitative estimation of its kinetic parameters. In this chapter, we present our approach to developing mathematical description of metabolic pathways. The model-based integration of reaction kinetics and the utilization of different types of experimental data including temporal dependencies have been described in detail. Software package DBSolve7 which allows us to develop kinetic model of the biochemical system and integrate experimental data has been presented.

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Year:  2009        PMID: 19597787     DOI: 10.1007/978-1-60761-175-2_11

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  4 in total

1.  Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach.

Authors:  Tatiana A Karelina; Kirill V Zhudenkov; Oleg O Demin; Dmitry V Svetlichny; Balaji Agoram; David Fairman; Oleg V Demin
Journal:  BMC Syst Biol       Date:  2012-11-12

2.  EI of the Phosphotransferase System of Escherichia coli: Mathematical Modeling Approach to Analysis of Its Kinetic Properties.

Authors:  T A Karelina; H Ma; I Goryanin; O V Demin
Journal:  J Biophys       Date:  2011-03-20

3.  Analysis of L-glutamic acid fermentation by using a dynamic metabolic simulation model of Escherichia coli.

Authors:  Yousuke Nishio; Soichi Ogishima; Masao Ichikawa; Yohei Yamada; Yoshihiro Usuda; Tadashi Masuda; Hiroshi Tanaka
Journal:  BMC Syst Biol       Date:  2013-09-22

4.  A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen.

Authors:  Galina Lebedeva; Azusa Yamaguchi; Simon P Langdon; Kenneth Macleod; David J Harrison
Journal:  BMC Syst Biol       Date:  2012-11-08
  4 in total

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